Improving on a previous attempt, scientists have developed a new strategy that could potentially be used to re-engineer a patient’s own immune system cells to fight HIV. The approach, described in PLOS Pathogens, shows benefit in human cell cultures and in mice. They did this through developing a new technique that builds on an earlier approach that made it to clinical trials. This relied on a chimeric antigen receptor (CAR) — a synthetic protein that when added to T cells allows them to fight a specific foe more effectively. In treatment, T cells extracted from a patient’s blood would be reengineered in the lab to express HIV-specific CARs, and then infused back into the patient to fight the virus. Other CAR-based techniques successfully enhance T cell attack of some cancer cells.
Improving on a previous attempt, scientists have developed a new strategy that could potentially be used to re-engineer a patient’s own immune system cells to fight HIV. The approach, described in PLOS Pathogens, shows benefit in human cell cultures and in mice. They did this through developing a new technique that builds on an earlier approach that made it to clinical trials. This relied on a chimeric antigen receptor (CAR) — a synthetic protein that when added to T cells allows them to fight a specific foe more effectively. In treatment, T cells extracted from a patient’s blood would be reengineered in the lab to express HIV-specific CARs, and then infused back into the patient to fight the virus. Other CAR-based techniques successfully enhance T cell attack of some cancer cells.
Improving on a previous attempt, scientists have developed a new strategy that could potentially be used to re-engineer a patient’s own immune system cells to fight HIV. The approach, described in PLOS Pathogens, shows benefit in human cell cultures and in mice. They did this through developing a new technique that builds on an earlier approach that made it to clinical trials. This relied on a chimeric antigen receptor (CAR) — a synthetic protein that when added to T cells allows them to fight a specific foe more effectively. In treatment, T cells extracted from a patient’s blood would be reengineered in the lab to express HIV-specific CARs, and then infused back into the patient to fight the virus. Other CAR-based techniques successfully enhance T cell attack of some cancer cells.
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